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時間：2015.6.5(五) 中午12:10
地點：醫學新館201室
講者：楊欣洲老師 (中研院統計科學研究所)
講題：Recovering the missing heritability of complex diseases
摘要：Since 2005, genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with complex diseases and traits. According to the NHGRI GWAS Catalog reports, up to the end of 2013, about 12 thousands of disease- or trait-associated SNPs from 1,750 curated publications have been reported. Nevertheless, missing heritability of complex diseases and traits is still a gap to be filled. In order to recover the missing heritability in GWAS, we developed statistical and bioinformatics tools to further enrich the collection of disease genes and mutations underlying complex diseases and traits. The developed analysis tools have been applied to study genetic mechanism and disease prognosis of hypertension, rheumatoid arthritis, schizophrenia, and acute lymphoblastic leukemia. The analyses include but are not limited to whole-genome sequencing data analysis, homozygosity disequilibrium analysis, gene- and pathway-based association and interaction analysis, copy number analysis, expression quantitative trait locus mapping, metabolomics data analysis, and integrative omics analysis. The analysis tools and their practical applications in medical research will be introduced in this talk.
承辦人：葉思妤
分機：5326 |
目前共有35人報名
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